Joan Puleo, left, uses the letter pieces from the game Upwords, to keep her partner, Charlie Calviello, 76, right, occupied. Calviello suffers from Alzheimer's. He's lost his long term and short term memory. AARP released a report Monday that said 42 million Americans are caregivers and the estimated economic impact was $450 billion in 2009, up from $375 billion two years earlier. Greg Kahn/Staff

Photo by GREG KAHN

Joan Puleo, left, uses the letter pieces from the game Upwords, to keep her partner, Charlie Calviello, 76, right, occupied. Calviello suffers from Alzheimer's. He's lost his long term and short term memory. AARP released a report Monday that said 42 million Americans are caregivers and the estimated economic impact was $450 billion in 2009, up from $375 billion two years earlier. Greg Kahn/Staff

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