A COVID-19 vaccine at what price? Should all Americans be able to get a shot for free?
How much should it cost the average American to get a COVID-19 vaccine shot in the arm?
Although a vaccine is months away, if not longer, billions of tax dollars are spent to rapidly research, develop, manufacture and distribute several candidates. The federal government promised to make a vaccine free for people of low income. How many taxpayer dollars would enable everyone to get it without paying?
That's not clear, in part because the government hasn't released the details of its contracts with vaccine developers, five of which will update members of Congress this morning on their efforts.
Drug companies should make some profit, because they've redirected thousands of employees to developing a COVID-19 vaccine in recent months, economists argue. If they don't make any money on the vaccine effort, they might be less likely to step up the next time the world is in dire need.
How much profit, if any, has been baked into the contracts hasn't been made public.
Written testimony in advance of today's committee hearing indicates some companies may initially give up or minimize profits.
A company that forgoes or minimizes profits this year might be able to more than recoup that investment in future years – if people need boosters or even annual shots to keep the virus at bay – while reaping good publicity for keeping the costs down now.
Sen. Patty Murray, D-Wash., said she wants the next COVID-19 relief package of $25 billion to include money ensuring a vaccine is free and available to every American. She doesn't know how much it will cost to do that, because the vaccines are still being developed and the administration hasn't released the contracts with drug companies.
"That is really disconcerting to me," she said in a phone interview. "We need transparency. We need to know this is above board. We need to have confidence that no one is making billions in a back room somewhere."
Several patient advocacy groups raised similar issues about the government's vaccine development program, called Operation Warp Speed.
"We have serious concerns regarding Operation Warp Speed's leadership, lack of transparency and coziness with the drug companies," Eli Zupnick, a spokesperson with the nonpartisan think-tank Accountable.US, said in an email. "If American taxpayers are shouldering the financial risk of vaccine development, then American patients should be guaranteed that any resulting vaccines be affordable and accessible and that drug companies aren't allowed to profiteer from them."
Cost of development
Many drug companies shy away from vaccine development because it's not a big moneymaker.
Vaccines usually sell for about $100 per shot in the USA and just $5-$10 in many other countries, said Andrew Lo, a finance professor at the MIT Sloan School of Management in Cambridge, Massachusetts. "When you use figures like that, the economics just don't work. It's just not profitable, which is one of the reasons more and more pharma companies have gotten out of the vaccine business."
In general, pharmaceutical companies argue they have to charge a lot for their products because drugs are so costly and time-consuming to develop. Drug candidates are made in test tubes, then tried on animals. It's an arduous process that can take a decade or more.
Then human testing begins, first with a few people to ensure basic safety, then hundreds and thousands more to prove continued safety and effectiveness. Even drug candidates that make it into early human testing fail more often than they succeed.
Those years of cost without guaranteed profit make drug development risky and medications expensive. In the case of COVID-19 vaccines, the federal government is taking away that risk, signing billion-dollar contracts with a handful of companies to design and manufacture candidate vaccines, agreeing to pay even if their product fails along the way.
That's why Dr. Steven Pearson, president of the Institute for Clinical and Economic Review (ICER), an independent nonprofit group, said Americans should not have to pay again to get vaccinated.
"It should cost less to nothing – at cost to produce it – if the federal government is doing the lion's share of the investment and development," he said.
Free or 'affordable'?
The federal government pledged to provide a successful vaccine to low-income Americans for no charge.
A spokesperson for the Department of Health and Human Services said, "Those doses the U.S. government purchases will be free." It remains unclear how many doses the government will purchase or whether it considers federal support for vaccine development to be "purchasing."
The price of a vaccine has not been determined, the spokesperson said, and declined to answer questions about any profit that might have been built into the contracts with drug companies.
Novavax, one of the companies developing a vaccine, committed to "affordable pricing" here and abroad.
The 33-year-old vaccine developer, which has not won approval for any of its products, received a federal contract worth $1.6 billion for development, manufacturing and distribution of its candidate vaccine, should it prove safe and effective. As part of that deal, Health and Human Services will own 100 million doses of the vaccine, called NVX-CoV2373, and the Department of Defense will own 10 million.
"Novavax is in the process of developing a thoughtful pricing strategy for our COVID-19 vaccine," a company spokesperson said via email. "To date we have focused on advancing the vaccine as quickly as possible and working with all of our government, non-profit and commercial partners to ensure equitable access throughout the globe, and any future pricing strategies will be consistent with that goal."
Another company in the race to develop a vaccine, pharmaceutical giant Astra Zeneca, said it hasn't made decisions about future pricing.
"We have made a commitment to make the potential vaccine available at no profit during the period of the pandemic to support broad and equitable access around the world," a company spokesman said via email. "As we continue to better understand our vaccine candidate, we will balance the intention to provide affordable pricing with the need for Novavax to make an appropriate return on investment that makes ongoing supply of our COVID-19 vaccine sustainable."
Insurance companies are essentially in the same position as average Americans when it comes to the price of a vaccine, said Dr. Katherine Dallow, vice president of clinical programs and strategy for Blue Cross Blue Shield of Massachusetts.
"We don't have negotiating power," she said. "The price is what the price is."
Many insurers, though not all, promised to pick up the cost of vaccination, so people will be able to get protection for free. In Massachusetts, Blue Cross committed to paying for a vaccine, just as it does for a flu vaccine, with no co-pay, Dallow said.
"We have maintained from the beginning of this pandemic that if and when a vaccine is developed that for our members, we will pay for it at no cost-share," she said. "So there is no barrier about deciding whether someone puts food on the table or gets a COVID immunization."
The cost of widespread vaccination is likely to be lower than the cost of hospitalizations for people who get seriously ill, she said.
Dallow said she hopes Congress and the administration ensure any vaccine is priced affordably "and also reflects taxpayer investment already put into place. For profits and margins to take over, for me, would be pretty unpalatable."
Changing vaccine development
To address COVID-19 and many other diseases, governments around the world need to have systemic policies for funding vaccine development, said Lo, the finance professor. "Vaccines are not like other commodities."
There is so little profit to be made in vaccines, that usually just one company develops each vaccine, with no competition or motivation to improve on shots, he said.
"It's ironic because a vaccine, if it's effective, protects you for, in many cases, the rest of your life, and yet we balk at paying $1,000 for that protection," Lo said. He noted that someone who has leukemia, for example, is charged $150,000 a year for life for the drug Gleevec, "and we think nothing of that."
Lo said the U.S. government should support vaccine development beyond COVID-19, providing a "reasonable" profit, which is usually assumed to be 8% to 12%.
"If a government can commit in advance to a fixed number of doses at a fixed price if and when an outbreak occurs, that takes a lot of uncertainty off the table for vaccine manufacturers," Lo said. "That by itself could be enough to reinvigorate and bring more money and more investors into this field."
Pearson, of the nonprofit group that analyzes drug prices, said that if companies make a good return on their involvement, it will encourage the industry to keep improving COVID-19 vaccines, assuming the first one to win approval won't be perfect.
"We're in uncharted territory," he said about pricing a vaccine in a pandemic. "It's really good to be raising these questions, because I don't think the public has really been thinking about it that much."
Contact Weintraub at kweintraub@usatoday.
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